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Furthermore, the accumulation of malondialdehyde, a marker of oxidative stress, has been observed in patients with -thalassemia, indicating heightened oxidative damage (77)

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In MOXIe Part 2, only 2 of 53 screen failures (3.8%) had a history of clinically significant liver disease or clinically relevant deviations in laboratory tests at screening (data on file provided by Biogen)